Analytical Biochemistry · 2007 · 106 citations · 42 references
MedicineMolecular BiologyOncologyCancer PharmacologyChemotherapyMolecular OncologyBiologic TherapeuticsDna ChemistryDna NanotechnologyLigand BindingNucleic Acid Drug DesignTargeting LigandsAptamer DesignAptamer DiscoveryAptamer EngineeringAptamer RecognitionAptamer-based BiosensingAptamer-based DetectionAptamers
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In vitro selection of RNA molecules that bind specific ligands
Andrew D. Ellington, Jack W. Szostak · Nature · 1990 · 9.7K citations
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
Louis C. Bock, Linda C. Griffin, John Latham et al. · Nature · 1992 · 2.5K citations