Polymorphic differences in the SOD-2 gene may affect the pathogenesis of nephropathy in patients with diabetes and diabetic complications

Biochemistry and molecular cell biology of diabetic complications

Michael Brownlee · Nature · 2001 · 9K citations

Life Sciences, Biochemistry, Cell Biology +14

The Pathobiology of Diabetic Complications

Michael Brownlee · Diabetes · 2005 · 5.3K citations · Full text

Medicine, Biomedical Sciences, Pathobiology +12

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Takeshi Nishikawa, Diane Edelstein, Xue Du et al. · Nature · 2000 · 4.3K citations

Life Sciences, Biochemistry, Physiology +14

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Yibing Li, Ting‐Ting Huang, Elaine J. Carlson et al. · Nature Genetics · 1995 · 1.8K citations

Medicine, Cardiology, Genetics +10

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Holly Van Remmen, Yuji Ikeno, Michelle M. Hamilton et al. · Physiological Genomics · 2003 · 733 citations

Life Sciences, Genetics, Molecular Biology +15