Concepedia

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate

Yuning Song, Xiaoqian Lin, Dongwei Kang, Xiao Li, Peng Zhan, Xinyong Liu, Qingzhu Zhang

European Journal of Medicinal Chemistry · 2014 · 40 citations · 18 references

DOI

Concepts

References

18

Activation of the phosphatase activity of human cdc25A by a cdk2‐cyclin E dependent phosphorylation at the G1/S transition.

Ingrid Hoffmann, Giulio Draetta, Eric Karsenti · The EMBO Journal · 1994 · 489 citations · Full text

, , +16

Cdc25A is a novel phosphatase functioning early in the cell cycle.

Shigeki Jinno, K. Sütö, A Nagata et al. · The EMBO Journal · 1994 · 450 citations · Full text

, , +14

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G <sub>2</sub> checkpoints

Hui Zhao, Janis L. Watkins, Helen Piwnica‐Worms · Proceedings of the National Academy of Sciences · 2002 · 450 citations · Full text

, , +17

Ectopic Expression of Cdc25A Accelerates the G <sub>1</sub> /S Transition and Leads to Premature Activation of Cyclin E- and Cyclin A-Dependent Kinases

Ida Blomberg, Ingrid Hoffmann · Molecular and Cellular Biology · 1999 · 295 citations

, , +17

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

Brian Gabrielli, Colin P. C. De Souza, Ian D. Tonks et al. · Journal of Cell Science · 1996 · 233 citations

, , +17