Amniotic Membrane Induces Peroxisome Proliferator-Activated Receptor-γ Positive Alternatively Activated Macrophages

Abstract

Based on these results it can be concluded that the action mechanism of AM is associated with modulation of classically activated macrophages into alternatively activated macrophages or macrophage cell death, probably by engaging lipid metabolism and activating the PPAR-γ pathway, consequently curtailing effector T cell functions. Apoptotic cells induced in the environment with AM support the presence and survival of such macrophages.