<i>In Utero</i> and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on <i>Cyp1a2</i> and <i>Ahr</i> Genotypes

Abstract

High levels of maternal hepatic CYP1A2 offer the most important protection against deficits in learning and memory in offspring exposed to a mixture of coplanar and noncoplanar PCBs. High-affinity AHR is the next most important factor in protection of offspring.