Potentiation of Antinociceptive Effects of Morphine by Calcium-channel Blockers at the Level of the Spinal Cord

Abstract

The authors interpreted these results to indicate that calcium-channel blocking drugs synergistically potentiate the analgesic effects of morphine at the level of the spinal cord. Before these results can be translated into clinical use, however, adequate toxicity studies must be conducted to examine the effect of the perispinal administration of calcium-channel blocking drugs on spinal cord function.