Angewandte Chemie International Edition in English · 1996 · 77 citations · 14 references
Life SciencesBiotechnologyMolecular BiologyNucleic Acid BiochemistryNucleic Acid ChemistryDna StructureNucleic Acid StructureNucleic Acid SynthesisOligonucleotide ChemistryRibonucleic Acid (Rna) ChemistryAutomated Dna SynthesisAutomated Synthesis ModulesChimera FormationOligonucleotide HybridizationOligonucleotide SynthesisPna Synthesis
Unambiguous binding to complementary DNA and RNA, stability toward 3′-exonucleases, and a similar uptake by cells as DNA oligomers characterize the PNA/DNA chimeras of type 1 described here. These chimeric oligomers are accessible in an automated synthesis sequence.
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DNA-like double helix formed by peptide nucleic acid
Pernilla Wittung‐Stafshede, Peter E. Nielsen, Ole Buchardt et al. · Nature · 1994 · 500 citations