Synthesis of Multisubstituted Imidazoles via Copper-Catalyzed [3 + 2] Cycloadditions

Abstract

A simple route for the synthesis of imidazole derivatives via copper-catalyzed [3 + 2] cycloaddition reaction is described. This strategy has achieved high regioselectivity and used oxygen as an oxidant without the addition of expensive catalysts to provide moderate to good yields.