Nucleic Acids Research · 1984 · 61 citations · 32 references
Life SciencesGeneticsMolecular BiologyDna RepairGenome EditingNucleic Acid BiochemistryDna DamageOccupational Genotoxic Exposure
A DNA recombining protein has been partly purified from cell lines derived from patients suffering from the hereditary disease, Bloom's syndrome. The protein induces the formation of displacement loops in phi X174 RFI DNA molecules after the addition of single-stranded DNA fragments. A filter binding method and electron microscopy were used to determine the reaction. The recombinogenic protein is dependent on divalent cations and ATP for activity.
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Takahiro Shibata, Chandan Dasgupta, Richard P. Cunningham et al. · Proceedings of the National Academy of Sciences · 1979 · 384 citations · Full text