Concepedia

Solid phase synthesis of 2,3-dihydro-4-pyridones: Reaction of Danishefsky's diene with polymer-bound imines

Tetrahedron Letters · 1997 · 62 citations · 26 references

Open access

Concepts

Combinatorial ChemistryNovel OrganocatalystsTandem Mannich-michael ReactionEngineeringPolymer-bound IminesOrganic ChemistrySolid Phase SynthesisStereoselective SynthesisChemistryHeterocycle ChemistryPolymer-bound AldiminesSynthesis MethodSolid SupportSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering

Abstract

An efficient method for the construction of 2,3-dihydro-4-pyridones on solid support has been developed, which utilized the Lewis-acid catalyzed tandem Mannich-Michael reaction of Danishefsky's diene with polymer-bound aldimines.

References

26

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Friedhelm Balkenhohl, Christoph von dem Bussche‐Hünnefeld, Annegret Lansky et al. · Angewandte Chemie International Edition in English · 1996 · 724 citations

Combinatorial Chemistry, Engineering, Molecular Biology +19

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Combinatorial Chemistry, Drug Design, Medicine +7

Organic Chemistry on Solid Supports

Jörg S. Früchtel, Günther Jung · Angewandte Chemie International Edition in English · 1996 · 647 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +19

Lanthanide Triflates as Water-Tolerant Lewis Acids. Activation of Commercial Formaldehyde Solution and Use in the Aldol Reaction of Silyl Enol Ethers with Aldehydes in Aqueous Media

Shu̅ Kobayashi, Iwao Hachiya · The Journal of Organic Chemistry · 1994 · 387 citations

Chemical Engineering, Chemical Measurement, Engineering +9

Asymmetric Hetero Diels-Alder Reactions

Herbert Waldmann · Synthesis · 1994 · 330 citations

Cross-coupling Reaction, Dienes 2.3.3, Dienes 3 +11