Anti‐nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A₁adenosine receptors

Abstract

Allopurinol-induced anti-nociception may be related to adenosine accumulation. Allopurinol is an old and extensively used compound and seems to be well tolerated with no obvious central nervous system toxic effects at high doses. This drug may be useful to treat pain syndromes in humans.