IL-12 AND NEUTRALIZATION OF ENDOGENOUS IL-10 REVERT THE IN VITRO ANTIGEN-SPECIFIC CELLULAR IMMUNOSUPPRESSION OF PARACOCCIDIOIDOMYCOSIS PATIENTS

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

N.G. Jacobson, Susanne J. Szabo, R Weber-Nordt et al. · The Journal of Experimental Medicine · 1995 · 668 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +19

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 α and STAT3 complexes in human T cells and monocytes

D S Finbloom, Karen D. Winestock · The Journal of Immunology · 1995 · 418 citations

Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1

Satoshi Ito, Parswa Ansari, Minoru Sakatsume et al. · Blood · 1999 · 392 citations

Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response.

Jared Gollob, J W Mier, Korina G. Veenstra et al. · PubMed · 2000 · 289 citations

Ifn-gamma Induction, Immunology, Immunoediting +16

Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy

Peter A. Sieling, J S Abrams, Masayuki Yamamura et al. · The Journal of Immunology · 1993 · 225 citations