Synthesis and evaluation of 4-substituted-4-androstene-3,17-dione derivatives as aromatase inhibitors

Source of Estrogen Production in Postmenopausal Women1

Jerrold Grodin, Pentti K. Siiteri, Paul C. MacDonald · The Journal of Clinical Endocrinology & Metabolism · 1973 · 962 citations

Fertility, Gynecology, Menopausal Hormone Therapy +27

Biological Aromatization of Steroids

Kenneth J. Ryan · Journal of Biological Chemistry · 1959 · 595 citations · Full text

Biochemistry, Medicine, Secondary Metabolite +5

The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization

E. Aubrey Thompson, Pentti K. Siiteri · Journal of Biological Chemistry · 1974 · 587 citations · Full text

Gynecology, Secondary Metabolite, Embryology +17

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer¹¹

Angela Brodie, William C. Schwarzel, Abubakar A. Shaikh et al. · Endocrinology · 1977 · 367 citations

4-Hydroxy-4-androstene- 3,17-Dione, Hormonal Contraceptive, Reproductive Health +25

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

Angela Brodie, Wesley M. Garrett, James R. Hendrickson et al. · Steroids · 1981 · 215 citations

Sustained Effects, Biosynthesis, Biochemistry +6