Concepedia

Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice

Sándor Kántor, Takatoshi Mochizuki, Stefan N. Lops, Brian Ko, Elizabeth Clain, Erika Clark, Mihoko Yamamoto, Thomas E. Scammell

SLEEP · 2013 · 56 citations · 45 references

DOIFull text

Open access

Abstract

These substantial improvements in sleepiness and other symptoms of narcolepsy demonstrate the effectiveness of orexin gene therapy in a mouse model of narcolepsy. Additional work is needed to optimize this approach, but in time, AAV-orexin could become a useful therapeutic option for patients with narcolepsy.

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