Efficacy and Safety of Lubiprostone in Patients with Chronic Constipation

Chronic constipation: a survey of the patient perspective

John F. Johanson, Jeffrey Kralstein · Alimentary Pharmacology & Therapeutics · 2007 · 619 citations · Full text

Medicine, Clinical Sciences, Chronic Illness Self-management +12

Epidemiology of Constipation (EPOC) Study in The United States: Relation of Clinical Subtypes to Sociodemographic Features

Walter F. Stewart, Joshua Liberman, Robert S. Sandler et al. · The American Journal of Gastroenterology · 1999 · 458 citations

Medicine, Clinical Sciences, Internal Medicine +17

Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Lubiprostone, a Locally-Acting Type-2 Chloride Channel Activator, in Patients With Chronic Constipation

John F. Johanson, Daniel Morton, Joseph E. Geenen et al. · The American Journal of Gastroenterology · 2007 · 330 citations

Pharmacy, Pharmacology, Pharmacotherapy +17

Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers

Michael Camilleri, Adil E. Bharucha, Ryuji Ueno et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2006 · 255 citations

Medicine, Pharmacology, Pharmacotherapy +17

SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents

John Cuppoletti, Danuta H. Malinowska, Kirti Tewari et al. · American Journal of Physiology-Cell Physiology · 2004 · 234 citations

Life Sciences, Molecular Biology, Physiology +17