Dextran Sulfate Suppression of Viruses in the HIV Family: Inhibition of Virion Binding to CD4 ⁺ Cells

Hiroaki Mitsuya, David J. Looney, S Kuno, +3

Science

ImmunologyImmunodominanceDextran SulfateAntiviral DrugImmune System +20

Clinical trial: lubiprostone in patients with constipation‐associated irritable bowel syndrome – results of two randomized, placebo‐controlled studies

Douglas A. Drossman, William D. Chey, John F. Johanson, +4

Alimentary Pharmacology & Therapeutics

Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Lubiprostone, a Locally-Acting Type-2 Chloride Channel Activator, in Patients With Chronic Constipation

John F. Johanson, Daniel Morton, Joseph E. Geenen, +1

The American Journal of Gastroenterology

Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers

Michael Camilleri, Adil E. Bharucha, Ryuji Ueno, +5

American Journal of Physiology-Gastrointestinal and Liver Physiology

NutritionFunctional Gastrointestinal DisorderGastrointestinal PharmacologyHealthy VolunteersPhysiology +12

SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents

John Cuppoletti, Danuta H. Malinowska, Kirti Tewari, +4

American Journal of Physiology-Cell Physiology

ImmunologyMolecular BiologyCellular PhysiologyMembrane TransportCell Signaling +16

Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double‐blind, placebo‐controlled, dose‐ranging study to evaluate efficacy and safety

John F. Johanson, Ryuji Ueno

Alimentary Pharmacology & Therapeutics

Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation

John F. Johanson, Douglas A. Drossman, Raymond M. Panas, +2

Alimentary Pharmacology & Therapeutics

Efficacy and Safety of Lubiprostone in Patients with Chronic Constipation

Charles F. Barish, Douglas A. Drossman, John F. Johanson, +1

Digestive Diseases and Sciences

Chronic ConstipationFunctional Gastrointestinal DisorderGastrointestinal PharmacologyMedicineGastroenterology +3

Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats

Ryuji Ueno, Youzou Ishikawa, Teruo Nakayama, +1

Biochemical and Biophysical Research Communications

SleepNeurophysiologyMedicinePhysiologyProstaglandin D2 Induces +10

Increased level of salivary prostaglandins in patients with major depression

Kazuhiro Ohishi, Ryuji Ueno, Seiji Nishino, +2

Biological Psychiatry

PsychiatryMood SymptomMajor DepressionDepressionBiological Psychiatry +4