Biochemical Evidence for Orphanin FQ/Nociceptin Receptor Heterogeneity in Mouse Brain

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Jean‐Claude Meunier, Catherine Mollereau, Lawrence Toll et al. · Nature · 1995 · 1.9K citations

Medicine, Medicinal Chemistry, Pharmacology +14

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

Rainer K. Reinscheid, Hans‐Peter Nothacker, Anne Bourson et al. · Science · 1995 · 1.8K citations

Medicine, Neuroscience, Pharmacology +17

ORL1, a novel member of the opioid receptor family

Catherine Mollereau, Marc Parmentier, Pierre Mailleux et al. · FEBS Letters · 1994 · 1.1K citations

Medicine, Molecular Biology, Pharmacology +17

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

James R. Bunzow, Carmen Sáez, Marty Mortrud et al. · FEBS Letters · 1994 · 605 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13