Association of the highly prevalent <i>TP53</i> R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in Southeast Brazil

Abstract

The current findings demonstrated compellingly that the TP53 R337H mutation is associated not only with ACT but also with CPC and, to a lesser extent, with osteosarcoma, both of which are core-component tumors of the Li-Fraumeni syndrome.