Characterization of Cytochrome P450 2A4 and 2A5-Catalyzed 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Metabolism

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Hepatology, Biochemistry, Carbon Monoxide-binding Pigment +9

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

Raija L.P. Lindberg, Masahiko Negishi · Nature · 1989 · 384 citations

Chemical Biology, Aldehyde Dehydrogenase, Biochemistry +10

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ta‐Chen Su, Ziping Bao, Qingyu Zhang et al. · PubMed · 2000 · 342 citations

Nasal Mucosa, Toxicological Mechanism, Respiratory Toxicology +16

EZ-FIT: A practical curve-fitting microcomputer program for the analysis of enzyme kinetic data on IBM-PC compatible computers

Frank W. Perrella · Analytical Biochemistry · 1988 · 269 citations

Enzyme Kinetic Data, Biochemistry, Ibm-pc Compatible Computers +9

O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.

Lisa A. Peterson, Stephen S. Hecht · PubMed · 1991 · 180 citations

Methylation Pathway, Chemoprevention Strategy, Dna Methylation +19