Concepedia

Massadine, a Novel Geranylgeranyltransferase Type I Inhibitor from the Marine Sponge <i>Stylissa</i> aff. <i>m</i> <i>assa</i>

Shinichi Nishimura, Shigeki Matsunaga, MITSUYOSHI SHIBAZAKI, Kenichi Suzuki, Kazuo Furihata, Rob W. M. van Soest, Nobuhiro Fusetani

Organic Letters · 2003 · 115 citations · 4 references

DOI

Abstract

Massadine, a highly oxygenated alkaloid, was isolated from the marine sponge Stylissa aff. massa as an inhibitor of geranylgeranyltransferase type I (GGTase I). The structure of massadine has been deduced from spectral data. Massidine inhibited GGTase I from Candida albicans with an IC(50) value of 3.9 microM. [structure: see text]

References

4

Isolation and structure of brevetoxin B from the "red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve)

Yong-Yeng Lin, Martin Risk, Sammy M. Ray et al. · Journal of the American Chemical Society · 1981 · 541 citations

, , +23

Sceptrin, an antimicrobial agent from the sponge Agelas sceptrum

Roger P. Walker, D. John Faulkner, Donna Van Engen et al. · Journal of the American Chemical Society · 1981 · 227 citations

, , +17

J-Resolved HMBC, a new NMR technique for measuring heteronuclear long-range coupling constants

Kazuo Furihata, Haruo Seto · Tetrahedron Letters · 1999 · 113 citations

, , +9

Corticatic Acids D and E, Polyacetylenic Geranylgeranyltransferase Type I Inhibitors, from the Marine Sponge <i>Petrosia</i> <i>c</i><i>orticata</i>

Shinichi Nishimura, Shigeki Matsunaga, MITSUYOSHI SHIBAZAKI et al. · Journal of Natural Products · 2002 · 32 citations