Corticatic Acids D and E, Polyacetylenic Geranylgeranyltransferase Type I Inhibitors, from the Marine Sponge <i>Petrosia</i> <i>c</i><i>orticata</i>

Abstract

Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compounds 1-3 inhibited GGTase I from Candida albicans with IC(50) values of 1.9-7.3 microM.