Virologic and Clinical Observations on Cytomegalic Inclusion Disease

Abstract

THE clinical entity referred to as cytomegalic inclusion disease, or generalized salivary-gland virus disease, has received increasing attention during the past decade. Concurrently, interest has shifted from the sphere of post-mortem diagnosis to the recognition of cases during life. This development followed the introduction of diagnostic procedures based on exfoliative cytologic studies1 2 3 and of technics for the isolation of the etiologic agents.4 5 6 Interest of clinicians initially was stimulated by the two case reports of Margileth7 and of Birdsong et al.,8 who, utilizing examination of urinary sediments to support the diagnosis, demonstrated that infants could survive the insults of neonatal cytomegalic . . .