Propagation in Tissue Cultures of a Cytopathogenic Virus from Human Salivary Gland Virus (SGV) Disease.

Abstract

ConclusionsA cytopathogenic virus inducing large intranuclear inclusions like those occurring in salivary gland virus disease has been isolated from the tissues of each of 2 infants. In both cases the virus has been propagated serially in cultures of human fibroblasts derived from uterine tissue. The distinctive cytopathogenic effects and the apparent species specificity of the 2 viruses, together with the isolation of each of the viruses from human tissue which contained the characteristic inclusions of salivary gland virus disease are substantial evidence that these viruses are strains of the human salivary gland virus.