FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression

Abstract

These findings demonstrate that FSTL1 up-regulates proinflammatory mediators important in the pathology of arthritis, and that serum levels of FSTL1 correlate with severity of arthritis. The latter supports the possibility that FSTL1 might be a target for treatment of certain forms of arthritis.