AAV-Mediated Gene Therapy for Retinal Degeneration in the<i>rd10</i>Mouse Containing a Recessive PDEβ Mutation

Abstract

These data demonstrate that P14 administration of AAV5-smCBA-PDEbeta can prevent retinal degeneration in rd10 mice, as reflected by significant structural, biochemical, electrophysiological, and behavioral preservation/restoration. These results serve as a baseline for studying long-term retinal rescue in rd10 mice.