Lipoatrophy Following the Injection of Insulin

Abstract

AMONG the many problems that have arisen since insulin was introduced as an agent in the treatment of diabetes mellitus is one concerned with the development of local fat atrophy at the site of insulin injections. Although of relatively infrequent occurrence, the problem has always proved to be very distressing to the patient because of the considerable amount of disfigurement it produces.Insulin lipoatrophy is a condition in which the subcutaneous fat disappears at the site of the insulin injection, leaving a depression in the skin (Fig. 1 and 2). It develops in some cases when the insulin is injected at . . .