New England Journal of Medicine · 2013 · 90 citations · 4 references
Life SciencesEndocrinologyPhysiologyCell DifferentiationCell PhysiologyDiabetologyDiabetes MellitusGlucose HomeostasisHormone SecretionInsulin ResistancePancreatic EndocrinologyPancreatic HormonesBeta Cell BiologyBeta-cell DysfunctionGlucose-stimulated Insulin SecretionInsulin Resistance SyndromePancreatic Beta-cell FunctionPancreatic Beta-cell SecretionType 2 Diabetes Mellitus PathogenesisType 2 Diabetes Pathophysiology
Type 2 diabetes is caused by enhanced insulin resistance and reduced insulin secretion. New data provide support for beta-cell dedifferentiation as a cause of reduced insulin secretion.
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