Peptide synthesis. Part 1. Preparation and use of polar supports based on poly(dimethylacrylamide)

Abstract

Details are given of the preparation of two functionalised polar support materials based on poly(dimethylacrylamide). Their solvation and other properties make them particularly suitable for solid-phase synthesis of polar substances, particularly of peptides and oligonucleotides, and also for solid-phase peptide and protein sequencing. Procedures are described for solid-phase peptide synthesis and are illustrated by preparation of a decapeptide.