Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells

Insulin-like growth factor II receptor as a multifunctional binding protein

David O. Morgan, Jeffrey C. Edman, David N. Standring et al. · Nature · 1987 · 855 citations

Life Sciences, Endocrinology, Molecular Biology +14

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

Marcelina Párrizas, Alan R. Saltiel, Derek LeRoith · Journal of Biological Chemistry · 1997 · 661 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.

M. Lau, Claire E. Stewart, Zhi Liu et al. · Genes & Development · 1994 · 607 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

Phillip A. Dennis, D B Rifkin · Proceedings of the National Academy of Sciences · 1991 · 515 citations

Life Sciences, Biochemistry, Cell Biology +13

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

Angus T. De Souza, Gerald R. Hankins, Mary K. Washington et al. · Nature Genetics · 1995 · 352 citations

Medicine, Genetics, Oncology +14