Organic Letters · 2007 · 29 citations · 10 references
Deceleration of the regioselective cis/trans isomerization of all-trans-astaxanthin (ASTX) in the presence of Ca2+ was shown by HPLC analysis. The NMR and ITC analyses provided evidence for complexation of ASTX with Ca2+ in 1:2 stoichiometry via chelation at both carbonyl and hydroxyl groups. The rotation across torsion omega6 (C5-C6-C7-C8) upon complexation is consistent with the NOE between 7-H and 5-CH3. This study supports the inhibitory effect of ASTX on calcium-induced turbidity of lens crystallins.
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Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice
Kazuhiko Uchiyama, Yuji Naito, Goji Hasegawa et al. · Redox Report · 2002 · 203 citations · Full text
Metabolic Syndrome, Diabetes Management, Insulin Signaling +15