Science · 1963 · 97 citations · 10 references
MedicineNephrologyPhysiologyRenal PathophysiologyBlood Pressure RegulationRenal Blood FlowRenal HemodynamicsRenal IschemiaRenal PhysiologyPlasma Renin ActivityRenal Hemodynamic EffectsRenal Perfusion EffectsRenal Perfusion Pressure
Small reductions in renal perfusion pressure to levels still within a physiologic range, which did not reduce renal blood flow, caused the kidney to release renin. Renin appeared in much larger amounts in renal-vein blood than in renal lymph. Release of reruin appears to be mediated by a renal baroceptor rather than by ischemia.
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THE RENAL ORIGIN OF HYPERTENSION
Harry Goldblatt · Physiological Reviews · 1947 · 286 citations
Medicine, Nephrology, Physiology +12
Angiotensinase with a High Degree of Specificity in Plasma and Red Cells
Philip A. Khairallah, F. Merlin Bumpus, Irvine H. Page et al. · Science · 1963 · 133 citations