PLoS Medicine · 2008 · 31 citations · 34 references
In 1995, the NINDS rt-PA study documented an improvement in neurologic outcomes at three months for those patients given rt-PA within 3 hours of onset of an acute ischemic stroke.
34
Contradicted and Initially Stronger Effects in Highly Cited Clinical Research
John P. A. Ioannidis · JAMA · 2005 · 1.5K citations
Early stroke treatment associated with better outcome
John R. Marler, Barbara C. Tilley, Mei Lü et al. · Neurology · 2000 · 869 citations
Use of Tissue-Type Plasminogen Activator for Acute Ischemic Stroke
Irene Katzan, Anthony J. Furlan, Lynne E. Lloyd et al. · JAMA · 2000 · 659 citations