Synthetic Communications · 2006 · 29 citations · 7 references
Chemical EngineeringEngineeringPara PositionAcetophenones Using 1,3‐Dichloro‐5,5‐dimethylhydantoinOrganic ChemistryHigh YieldChemistryHeterocycle ChemistryHalogenationP‐toluenesulfonic AcidSynthetic Chemistry
Abstract A novel method for the synthesis of α‐chloroacetophenones using 1,3‐dichloro‐5,5‐dimethylhydantoin (DCDMH) and p‐toluenesulfonic acid in methanol at 30–35°C is described. Substituted acetophenones at the para position or meta position of aromatic ring give α‐chloroacetophenones in high yield. However, reaction of o‐nitroacetophenone does not take place under the same condition.
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Hisao Eguchi, Hideichiro Kawaguchi, Sachiyo Yoshinaga et al. · Bulletin of the Chemical Society of Japan · 1994 · 54 citations
Chemical Engineering, Enantioselective Synthesis, Engineering +10