Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao, +5

Nature

Developmental BiologyAutoimmune DiseaseLymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune System +11

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou, +5

Cell

InflammationCytokineLymphocyte DevelopmentImmune RegulationImmunology +7

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang, +8

Nature Immunology

InflammationAutoimmune DiseaseTissue InflammationLymphocyte DevelopmentT-regulatory Cell +9

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins, +2

Immunity

InflammationCytokineLymphocyte DevelopmentImmune Cell DevelopmentImmunology +7

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn, +7

Nature

Developmental BiologyTh17 LineageCell ProliferationCell GrowthGene Expression +1

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

Spencer C. Liang, Xiangyang Tan, Deborah Luxenberg, +4

The Journal of Experimental Medicine

Microbial PathogensImmunologyImmune RegulationEnhance ExpressionAntimicrobial Peptides +16

Development, cytokine profile and function of human interleukin 17–producing helper T cells

Nicholas J. Wilson, Katia Boniface, Jason R. Chan, +13

Nature Immunology

InflammationCytokineImmune Cell DevelopmentImmunologyT Cell Immunity +8

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Eva V. Acosta Rodríguez, Giorgio Napolitani, Antonio Lanzavecchia, +1

Nature Immunology

InflammationCytokineLymphocyte DevelopmentImmune Cell DevelopmentImmunology +9

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

Yutaka Komiyama, Susumu Nakae, Taizo Matsuki, +5

The Journal of Immunology

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

David Yen, Jeanne Cheung, Heleen Scheerens, +12

Journal of Clinical Investigation

Chronic Inflammatory DiseasesImmunologyImmune RegulationPathologyMouse Ibd Studies +15