Concepedia

Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension

Mark L. Ormiston, Chiwen Chang, Lü Long, Elaine Soon, Des C. Jones, Rajiv D. Machado, Carmen Treacy, Mark Toshner, Kate Campbell, Alex Riding,

Circulation · 2012 · 118 citations · 32 references

DOIFull text

Open access

Abstract

Our work is the first to identify an impairment of NK cells in PAH and suggests a novel and substantive role for innate immunity in the pathobiology of this disease.

References

32

Pulmonary Arterial Hypertension in France

Marc Humbert, Olivier Sitbon, Ari Chaouat et al. · American Journal of Respiratory and Critical Care Medicine · 2006 · 2K citations

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Jacob H. Hanna, Debra Goldman‐Wohl, Yaron Hamani et al. · Nature Medicine · 2006 · 1.6K citations

, , +14

Human NK Cell Education by Inhibitory Receptors for MHC Class I

Nicolas Anfossi, Pascale André, Sophie Guia et al. · Immunity · 2006 · 1.1K citations · Full text

, , +10

Reversal of experimental pulmonary hypertension by PDGF inhibition

Ralph T. Schermuly · Journal of Clinical Investigation · 2005 · 1K citations · Full text

, , +16

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

Elaine Soon, Alan Holmes, Carmen Treacy et al. · Circulation · 2010 · 789 citations