Concepedia

Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors

Mark L. Weber, Corry M. Hofland, Christopher L. Shaffer, Gunnar Flik, Thomas I.F.H. Cremers, Raymond S Hurst, Hans Rollema

Neuropharmacology · 2013 · 19 citations · 37 references

DOI

Concepts

References

37

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

DavidS. Janowsky, JohnM. Davis, M. Khaled El‐Yousef et al. · The Lancet · 1972 · 1.1K citations

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Treatment-resistant depression: therapeutic trends, challenges, and future directions

Alharbi Alharbi · Patient Preference and Adherence · 2012 · 770 citations · Full text

, , +16

Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

Hans Rollema, Leslie K. Chambers, J.W. Coe et al. · Neuropharmacology · 2006 · 535 citations

, , +14

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

J. Cory Kalvass, Tristan S. Maurer · Biopharmaceutics & Drug Disposition · 2002 · 415 citations

, , +15

Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction

Scott Summerfield, Kevin D. Read, David J. Begley et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 284 citations

, , +17