Concepedia

Decreased collagen‐induced arthritis severity and adaptive immunity in MKK‐6–deficient mice

Deepa Hammaker, Katharyn Topolewski, Meghan Edgar, Toshio Yoshizawa, Akihisa Fukushima, David L. Boyle, Esther Cory Burak, Robert L. Sah, Gary S. Firestein

Arthritis & Rheumatism · 2011 · 19 citations · 31 references

DOI

Abstract

Reduced disease severity in MKK-6(-/-) mice correlated with decreased anticollagen antibody responses, indicating that MKK-6 is a crucial regulator of inflammatory joint destruction in CIA. MKK-6 is a potential therapeutic target in complex diseases involving adaptive immune responses, such as RA.

References

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Danielle Diarra, Marina Stolina, Karin Polzer et al. · Nature Medicine · 2007 · 1.3K citations

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Meike Mitsdoerffer, Youjin Lee, Anneli Jäger et al. · Proceedings of the National Academy of Sciences · 2010 · 524 citations · Full text