Drug Development and Industrial Pharmacy · 2006 · 211 citations · 6 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryPharmaceutical FormulationDrug EncapsulationLipid-based Drug Delivery SystemsLipid-based NanoparticlesNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanoparticle FormulationsEncapsulation EfficiencyIn-vitro CharacterizationLipid Nanoparticle Delivery SystemsLipid-based EncapsulationLipid-based Nanoparticle FormulationMicroemulsion SystemsNanocarrier Encapsulation EfficiencyTopical Gels
Nanostructured Lipid Carrier (NLC)-based topical gel of Valdecoxib was formulated with the aim of faster onset yet prolonged action for the treatment of inflammation and allied conditions. NLCs prepared by microemulsion template technique were characterized by photon correlation spectroscopy for size. Drug encapsulation efficiency was determined using Nanosep centrifugal device. The nanoparticulate dispersion was suitably gelled and characterized with respect to drug content, pH, spreadibility, rheology, and in-vitro release. Safety of the NLC-based gel was assessed using primary skin irritation studies, and efficacy was confirmed using pharmacodynamic study, namely the Aerosil-induced Rat Paw edema model. The developed NLC-based gel showed faster onset and elicited prolonged activity up to 24 hours.
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