Characterization of ‘adult‐type’ mast cells derived from human bone marrow CD34⁺ cells cultured in the presence of stem cell factor and interleukin‐6. Interleukin‐4 is not required for constitutive expression of CD54, FcεRI<i>α</i> and chymase, and CD13 expression is reduced during differentiation

Abstract

CD34(+) progenitors of human bone marrow are a rich source of mast cell progenitors capable of expressing granule and surface markers of mature mast cells in the presence of rhSCF and rhIL-6.