Insulin secretory defects and impaired islet architecture in pancreatic β-cell-specific STAT3 knockout mice

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Margherita Maffei, Jeffrey L. Halaas, Éric Ravussin et al. · Nature Medicine · 1995 · 3.7K citations

Obesity, Metabolic Syndrome, Energy Homeostasis +11

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

Zhong Zhong, Zilong Wen, James Darnell · Science · 1994 · 2.1K citations

Targeted disruption of the mouse <i>Stat3</i> gene leads to early embryonic lethality

Kiyoshi Takeda, Koichi Noguchi, Wei Shi et al. · Proceedings of the National Academy of Sciences · 1997 · 1.3K citations

Genetics, Immunology, Stat3-deficient Embryos +16

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Catherine Postic, Masakazu Shiota, Kevin D. Niswender et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

Kiyoshi Takeda, Björn E. Clausen, Tsuneyasu Kaisho et al. · Immunity · 1999 · 1.2K citations · Full text

Inflammation, Cytokine, Mice Devoid +10