Normal Tyrosine Transport and Abnormal Tyrosinase Routing inPink-Eyed DilutionMelanocytes

A line of non‐tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth

Dorothy C. Bennett, Philip J. Cooper, Ian R. Hart · International Journal of Cancer · 1987 · 484 citations

Medicine, Cell Biology, Oncology +9

A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism

Eugene M. Rinchik, Scott J. Bultman, Bernhard Horsthemke et al. · Nature · 1993 · 415 citations

Medicine, Genetics, Molecular Genetics +14

Cystine Transport Is Defective in Isolated Leukocyte Lysosomes from Patients with Cystinosis

W. A. Gahl, Nava Bashan, Frank Tietze et al. · Science · 1982 · 364 citations

Life Sciences, Biochemistry, Cell Biology +17

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

Ruth Halaban, Elaine Cheng, Yuhua Zhang et al. · Proceedings of the National Academy of Sciences · 1997 · 259 citations

Life Sciences, Biochemistry, Oncology +17

Tyrosinases from two different loci are expressed by normal and by transformed melanocytes.

María I. Jiménez, Katsuhiko Tsukamoto, Vincent J. Hearing · Journal of Biological Chemistry · 1991 · 233 citations · Full text

Life Sciences, Biochemistry, Genetics +13