Resuscitation with Lactated Ringer's Solution in Rats with Hemorrhagic Shock Induces Immediate Apoptosis

Abstract

Resuscitation with LR solution after hemorrhagic shock increased immediate cell death by apoptosis in both the small intestine and liver. There was no significant increase in apoptosis in the animals resuscitated with hypertonic saline, whole blood, or in unresuscitated animals. Thus, the type of resuscitation fluid used may affect the apoptotic cellular response to shock.