Interaction of pyrin with 14.3.3 in an Isoform‐specific and phosphorylation‐dependent manner regulates its translocation to the nucleus

Abstract

These results disclose the role played by 14.3.3 in the regulation of the subcellular compartmentalization of pyrin in a phosphorylation- and isoform-dependent manner. They also reconcile the observations made in vitro with those made in vivo, while providing a direct link between 14.3.3-dependent pathways and pyrin.