Concepedia

Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection

Naoto Inoue, Eisuke Takai, Tsutomu Arakawa, Kentaro Shiraki

Journal of Bioscience and Bioengineering · 2013 · 80 citations · 34 references

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References

34

Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

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Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution

Jun Liu, Mary D.H. Nguyen, James D. Andya et al. · Journal of Pharmaceutical Sciences · 2005 · 439 citations

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The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation

Tsutomu Arakawa, Kouhei Tsumoto · Biochemical and Biophysical Research Communications · 2003 · 359 citations

, , +14

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

Sonoko Kanai, Jun Liu, Thomas W. Patapoff et al. · Journal of Pharmaceutical Sciences · 2008 · 305 citations

, , +17

The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions

Sandeep Yadav, Thomas M. Laue, Devendra S. Kalonia et al. · Molecular Pharmaceutics · 2012 · 278 citations

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