Luminal hypotonicity increases duodenal mucosal permeability by a mechanism involving 5‐hydroxytryptamine

Abstract

Luminal hypotonicity increases duodenal mucosal permeability by a neural mechanism involving 5-HT acting on 5-HT(3) and 5-HT(4) receptors. 5-HT also appears to participate in the regulation of the hypotonicity-induced fluid flux.