Impact of Using Different Promoters and Matrix Attachment Regions on Recombinant Protein Expression Level and Stability in Stably Transfected CHO Cells

The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

Albert Jordan · The EMBO Journal · 2001 · 474 citations · Full text

Tat Transactivation, Transcriptional Regulation, Viral Replication +13

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

Richard Festenstein, Mauro Tolaini, Paola Corbella et al. · Science · 1996 · 367 citations

A study of monoclonal antibody‐producing CHO cell lines: What makes a stable high producer?

Janet Chusainow, Yuansheng Yang, Jessna H. M. Yeo et al. · Biotechnology and Bioengineering · 2008 · 306 citations · Full text

Gene Amplification, Genetics, Immunology +20

Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure

Sang Jick Kim, No Soo Kim, Chun Jeih Ryu et al. · Biotechnology and Bioengineering · 1998 · 221 citations

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor1α promoter

SE Smyth, CA Goddard, I. A. Pringle et al. · Gene Therapy · 2001 · 213 citations

Lung Gene Expression, Transcriptional Regulation, Inflammatory Lung Disease +10