Cardioprotection by Ecto-5′-Nucleotidase (CD73) and A _2B Adenosine Receptors

Abstract

Taken together, pharmacological and genetic evidence demonstrate the importance of CD73-dependent adenosine generation and signaling through A2B AR for cardioprotection by ischemic preconditioning and suggests 5'-nucleotidase or A2B AR agonists as therapy for myocardial ischemia.