Pharmacologic evaluation of various metabolites and analogs of valproic acid: Teratogenic potencies in mice

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

Heinz Nau, D. Rating, S. Koch et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 231 citations

Medicine, Pharmacokinetics, Pharmacology +17

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

Heinz Nau, Rainer Zierer, Horst Spielmann et al. · Life Sciences · 1981 · 169 citations

Pharmacy, Pharmacokinetics, Toxicology +17

Teratogenicity of valproic acid: In vivo and in vitro investigations

John Y. Kao, Nigel A. Brown, Eugenia H. Goulding et al. · Teratogenesis Carcinogenesis and Mutagenesis · 1981 · 163 citations

Life Sciences, Developmental Biology, Pharmacology +17

Pharmacological evaluation of various metabolites and analogues of valproic acidAnticonvulsant and toxic potencies in mice

W Löscher, Heinz Nau · Neuropharmacology · 1985 · 135 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Valproic acid in the perinatal period: Decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites

Heinz Nau, H Helge, W. A. P. Luck · The Journal of Pediatrics · 1984 · 110 citations

Medicine, Obstetrics, Pharmacology +17