Flow rate gradient high-speed counter-current chromatography separation of five diterpenoids from Triperygium wilfordii and scale-up

Triptolide inhibits the growth and metastasis of solid tumors.

Shanmin Yang, Jinguo Chen, Zhen Guo et al. · PubMed · 2003 · 281 citations

Antitumor Properties, Solid Tumors, Medicine +11

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

Bing Z. Carter, Duncan H. Mak, Wendy Schober et al. · Blood · 2006 · 202 citations · Full text

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells

Xiaohua Jiang, Benjamin Chun–Yu Wong, Marie C.M. Lin et al. · Oncogene · 2001 · 192 citations

Triptolide-induced Apoptosis, Functional P53, Gastric Cancer Cells +13

Triptolide and Chemotherapy Cooperate in Tumor Cell Apoptosis

Wenteh Chang, Jason Kang, Kye-Young Lee et al. · Journal of Biological Chemistry · 2001 · 163 citations · Full text

Diterpene Triepoxide, P53-responsive Gene, Medicine +13

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii

Lisa A. Shamon, John M. Pezzuto, Jewell Graves et al. · Cancer Letters · 1997 · 162 citations

Medicinal Chemistry, Biochemistry, Oxygenated Diterpene +9