The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

Mary F. Lyon · Nature · 1961 · 4K citations

Knockout Mouse, Developmental Biology, Cytogenetics +8

A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

Carolyn J. Brown, Andrea Ballabio, James L. Rupert et al. · Nature · 1991 · 1.5K citations

Chromatin, Developmental Biology, Genetic Disorder +9

The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

Carolyn J. Brown, Brian Hendrich, Jim L. Rupert et al. · Cell · 1992 · 1.3K citations

Chromatin, Systems Biology, Engineering +8

A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein Synthesis

Murray L. Barr, Ewart G. Bertram · Nature · 1949 · 1K citations

Biology, Chromatin, Chromosome Dynamics +14

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

Neil Brockdorff, Alan Ashworth, Graham F. Kay et al. · Cell · 1992 · 1K citations

Genetics, Gene Structure, Gene Regulation +7